Increased transmission potential of Leishmania major/Leishmania infantum hybrids

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Increased transmission potential of Leishmania major/Leishmania infantum hybrids.

Development of Leishmania infantum/Leishmania major hybrids was studied in two sand fly species. In Phlebotomus papatasi, which supported development of L. major but not L. infantum, the hybrids produced heavy late-stage infections with high numbers of metacyclic promastigotes. In the permissive vector Lutzomyia longipalpis, all Leishmania strains included in this study developed well. Hybrids ...

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Vectorborne Transmission of Leishmania infantum from Hounds, United States

Leishmaniasis is a zoonotic disease caused by predominantly vectorborne Leishmania spp. In the United States, canine visceral leishmaniasis is common among hounds, and L. infantum vertical transmission among hounds has been confirmed. We found that L. infantum from hounds remains infective in sandflies, underscoring the risk for human exposure by vectorborne transmission.

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The Antileishmanial Potential of C-3 Functionalized Isobenzofuranones against Leishmania (Leishmania) Infantum Chagasi.

Leishmaniases are diseases caused by protozoan parasites of the genus Leishmania. Clinically, leishmaniases range from cutaneous to visceral forms, with estimated global incidences of 1.2 and 0.4 million cases per year, respectively. The treatment of these diseases relies on multiple parenteral injections with pentavalent antimonials or amphotericin B. However, these pharmaceuticals are either ...

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Final comments on an interesting taxonomic dilemma: Leishmania infantum versus Leishmania infantum chagasi.

It is grateful to see that the new session “Readers’ opinion and discussion” created after my comments – “Leishmania infantum versus Leishmania chagasi: do not forget the law of priority” (Dantas-Torres 2006) – on the concise review article of Lainson and Rangel (2005) has emerged as the basis of an interesting debate on the aetiological agent of American visceral leishmaniasis, i.e., the taxon...

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Genes and chromosomes of Leishmania infantum.

During recent years, several Leishmania infantum genes have been cloned and characterized. Here, we have summarized the available information on the gene organization and expression in this protozoan parasite. From a comparative analysis, the following outstanding features were found to be common to most of the genes characterized: tandemly organized genes with conserved coding regions and dive...

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ژورنال

عنوان ژورنال: International Journal for Parasitology

سال: 2007

ISSN: 0020-7519

DOI: 10.1016/j.ijpara.2007.02.002